Neuroscientists have identified that the receptor IL-1R1 plays a critical role in enabling neurons to directly communicate with the immune system. The new study provides the most detailed mapping of ...

A comprehensive study mapped neuronal IL-1R1 (nIL-1R1) expression in the mouse brain, highlighting its role in sensory ...

Interleukin-1 (IL-1) is a key molecule involved in inflammation and plays an important role in both healthy and diseased ...

Interleukin-1 (IL-1) is a key molecule involved in inflammation and plays an important role in both healthy and diseased states. In disease, high ...

The somatosensory system consists of the peripheral receptors and neural pathways through which the nervous system detects and processes information about touch (mechanoception), pain (nociception ...

Layer 5 pyramidal neurons, crucial for brain information processing, vary significantly in their synaptic protein composition based on neuron type.

Notably, this coupling crumbles with age in mice. Restoring it not only bolstered neuronal energy reserves, but also strengthened synaptic signaling and counteracted memory loss in old animals.

We know that social rejection activates the same pain receptors in our brain as physical ... Social rejection shares somatosensory representations with physical pain. Proc Natl Acad Sci U S ...

somatosensory system, gustatory system and vestibular system. Sensory systems are composed of receptors that sense the sensory stimuli, brain areas involved in sensory perception and neural ...

Exactly how external loads open MeT channels in somatosensory neurons remains unknown ... Nat Cell Biol, 2014) regulate touch receptor neuron mechanics and that both elements are needed for normal ...

Similarly, the primary function of the somatosensory branch of the peripheral nervous ... of neuropeptide expression and/or immune cell-specific ablation of neuropeptide receptors could potentially ...