Administration of alemtuzumab, a humanized antibody to target CD52, to a patient with diffuse cutaneous SSc resulted in sustained improvement in the skin. Tocilizumab, an anti-IL-6 receptor ...

2 The same review noted that tocilizumab, a humanized monoclonal antibody against interleukin-6 receptor, might have a role in treating severe, active, corticosteroid-resistant TED, although more ...

By leveraging multi-platform strategies, including humanized mouse models, human tumor antigen transgenic mice, patient-derived xenografts, and advanced in vitro/ex vivo organoid/tumor explant systems ...

Tocilizumab is effective and safe for rheumatoid arthritis, with long-term studies supporting its use and comparable cardiovascular risk to tumor necrosis factor inhibitors. Real-world data ...

DELRAY BEACH, Fla., April 22, 2025 /PRNewswire/ -- The global Humanized Mouse and Rat Model Market, valued at US$255.8 million in 2024, is forecasted to grow at a robust CAGR of 8.2%, reaching US$ ...

Purpose: The pharmacology, pharmacokinetics, clinical efficacy, safety, and role of tocilizumab in rheumatoid arthritis (RA) are reviewed. Summary: Tocilizumab is a novel monoclonal antibody that ...

It is the second drug to be specifically approved for the disease in the United States after tocilizumab in 2017. The FDA has approved the Janus kinase inhibitor upadacitinib for the treatment of ...

former post-docs in the Ho lab who now lead their own labs at Taipei Medical University in Taiwan-have developed a humanized antibody to dismantle that barrier as a potential cancer immunotherapy.

Advances in RA treatment require improved understanding of patient-specific therapy appropriateness, focusing on disease pathogenesis and heterogeneity. Current RA treatment algorithms lack ...

When these humanized organoids were transplanted into rodents whose own liver-bile duct system had been disconnected, the improved organoids nearly doubled the rodents' survival rate. The research ...