It binds both transmembrane and soluble TREM2, triggering a rise in CSF sTREM2. Single and multi-dose studies of the small ...

Single and multi-dose studies of the small molecule TREM2 agonist VG-3927 clear early safety hurdle. Meanwhile, new findings ...

IgA nephropathy (IgAN) is an autoimmune disorder that affects the kidneys by impairing the filtration function of the small ...

For treating brain diseases, the bispecific antibodies from Grabody contain a domain designed to bind to insulin-like growth factor 1 receptor (IGF1R), a receptor that transports proteins across ...

GC-A is a type of single-pass transmembrane receptor protein that spans the cell membrane, connecting a binding region on the cell surface to an interior signaling domain, allowing it to transmit ...

Allosteric sites in the cytoplasmic domain. The intracellular loop that links the TM3 and TM4 transmembrane segment is unique to eukaryotic receptors but remains a largely unexplored territory for ...

Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their ...

The NRP-1 receptor is an essential transmembrane glycoprotein involved in the development of the nervous and cardiovascular systems, as well as immune regulation, and may play a role in diabetes ...

Sweden: A recent study published in Diabetes, Obesity and Metabolism has identified a potential biological marker tied to ...

IGF1R is a transmembrane receptor found on the BBB, a semi-permeable membrane between the blood and the network of fluid-filled spaces and connective tissue that surrounds the brain and is ...

André Briend is the 2025 recipient of the John Dirks Canada Gairdner Global Health Award, which recognizes outstanding ...