Cardiomyopathies are diseases of the heart muscle. This group of pathological conditions includes dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic ...

High-intensity exercise raises sudden cardiac death risk in young hypertrophic cardiomyopathy patients, independent of ...

Cardiomyopathies encompass a number of disorders related to distinct genetic mutations, such as hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular ...

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular ... 30 40 41 LVOTO at rest and Valsalva. LA volume is probably a more accurate measurement than LA diameter, but no data are ...

The burgeoning evidence of patients diagnosed with sigmoidal hypertrophic cardiomyopathy (HCM) later in life has revived the quest for distinctive features that may help discriminate it from more ...

There are several forms, each with different symptoms. Most types of cardiomyopathy are marked by an eventual enlargement of the heart, which makes the heart unable to pump blood properly.

The decrease in mortality, morbidity were seen with trametinib for children with RASopathy-associated hypertrophic cardiomyopathy. HealthDay News — For children with severe hypertrophic cardiomyopathy ...

The United States (US) Food and Drug Administration (FDA) approved mavacamten for the treatment of obstructive hypertrophic cardiomyopathy (HCM ... required a dose reduction due to Valsalva LV outflow ...

Mavacamten is a first-in-class cardiac myosin ATPase inhibitor, approved by the United States Food and Drug Administration for the treatment of hypertrophic cardiomyopathy with obstructive physiology ...

The delivery of the Cas9 endonuclease complexed with a synthetic guide RNA (gRNA) into cells induces double-strand DNA breaks at a precise genome location close to a protospacer adjacent motif, which ...

More than 600 different sarcomeric gene mutations are reported in patients with HCM. 8 – 16 The majority are missense mutations, but nonsense, frameshift, and in-frame insertion/deletion mutations ...