San Francisco 49ers rookie RB Isaac Guerendo suffered MCL and ankle sprains against the Arizona Cardinals, avoiding an ACL ...

The San Francisco 49ers can breathe a sigh of relief following the latest update on Isaac Guerendo’s injury status. However, ...

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers' season finale versus the Arizona ...

Unfortunately, San Francisco 49ers' running back Isaac Guerendo was carted off the field early in the first quarter.

Rookie running back Isaac Guerendo was carted off the field less than two minutes into the first quarter during the 49ers’ ...

The 49ers lost their standout rookie Isaac Guerendo in scary fashion. What update did the running back provide Monday?

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...

San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN's Adam Schefter. Guerendo has been limited in practice this week ...

Coach Kyle Shanahan said Monday that the 49ers expect Guerendo (foot/hamstring) to practice Thursday, Nick Wagoner of ESPN.com reports. Guerendo picked up foot and hamstring injuries in Week 15 ...

Guerendo now has managed back-to-back capped sessions to kick off Week 17 prep as he looks to put foot and hamstring injuries further in the rearview mirror. He sat out the 49ers' Week 16 loss at ...

After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday’s game vs. Miami.

San Francisco 49ers running back Isaac Guerendo. / Bob Kupbens-Imagn Images The San Francisco 49ers are already down Jordan Mason and Christian McCaffrey in their backfield (both are on injured ...