Scientists develop new natural killer cell strategy to target HIV
Researchers at The Wistar Institute's HIV Cure and Viral Diseases Center have successfully identified a new approach using ...
eLife9d
Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis
The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...
thorax.bmj14d
Inflammation in preschool cystic fibrosis is of mixed phenotype, extends beyond the lung and is differentially modified by CFTR modulators
Background Early-life inflammation has long been recognised as a key pathophysiological process in the evolution of cystic ...
Business Wire11d
HealthBioâ„¢ Therapeutics Begins FDA-Approved Fast-Track Clinical Trial for Treatment of Long COVID with a Patented Combination of Maraviroc and Atorvastatin
Earlier research published in Frontiers on Immunology (Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection), supports ...
gut.bmj12d
Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system
Dissociated cells were incubated with Zombie Aqua Viability (Biolegend, San Diego, California, USA) followed by blocking with 5% rat serum and mouse anti-CD16/CD32 (eBioscience, San Diego, California, ...
Frontiers16d
FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors
Cells were counted using a Sysmex hematology analyzer (Sysmex). Cells were incubated with Fc-blocking antibodies (CD16/32, clone: 93, BD) prior to staining with fluorescently labeled antibodies. For ...
Cancer Research12d
The FcγRIIIA (CD16) L48-H/R Polymorphism Enhances NK Cell–Mediated Antibody-Dependent Cellular Cytotoxicity by Promoting Serial Killing
1Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
gut.bmj6d
Reparative immunological consequences of stem cell transplantation as a cellular therapy for refractory Crohn’s disease
Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain ...
The New England Journal of Medicine18d
Hemophagocytic Lymphohistiocytosis
Familial HLH is a success story in modern medicine. Initially a disease that was largely unknown and fatal, it is now understood on a molecular level and is curable. Moreover, HLH is an archetype ...