How do antibody engineers select isotypes ... Human IgG4 was exchanged for human IgG1 within the constant region of keliximab, and two variants (IgG4-E and IgG4-PE) were tested.
class switching in the heavy-chain constant region, and increased affinity for antigen in the variable region. In 1991, I was invited to work at the National Institutes of Health as a Fogarty Scholar.
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