C&EN15d
Biosynthesis of Dothideomins Reveals a Fungal P450 That Constructs the Tricyclo[5.2.2.0. 4,8]undecane-Imbedded Core Skeleton
School of Medicine and Pharmacy, Key Laboratory of Marine Drugs Ministry of Education, Sanya Oceanographic Institute, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean ...
C&EN22d
Cytochrome P450-Catalyzed Tetrahydrofuran Formation via Dual Pathways in Avermectin Biosynthesis
State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, ...
gut.bmj25d
Blocking hepatocarcinogenesis by a cytochrome P450 family member with female-preferential expression
A member of cytochrome P450 family, CYP39A1, was one of the top liver-specific candidates with significantly higher levels in female vs male liver. In HCC tumours, CYP39A1 expression was dramatically ...
Frontiers2y
The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage
FIGURE 2. P450-active cycle exemplified for GPA crosslinking together with the heme oxygenase degradation pathway. PCP-X construct. The PCP-X construct from the kistamicin NRPS was expressed and ...
Frontiers6y
Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug
Metoprolol is used for phenotyping of cytochrome P450 (CYP) 2D6, a CYP isoform considered not to be inducible by inducers of the CYP2C, CYP2B, and CYP3A families such as rifampicin. While assessing ...