Histamine receptor, a typical G-protein-coupled receptor (GPCR), is important mediator of signalling and is responsible for regulation of human autoimmunity. Here, the authors report an artificial ...

Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology. A sustained ...

As discussions intensify about how the second Trump administration will reshape the regulatory landscape for U.S.-based life sciences firms, ...

Increasing numbers of young people are using the drug, experts say. The health impacts can be catastrophic. Jayne Donn says her son, James, died in 2022 from a drug overdose aged 29. The 60-year ...

Too much of anything can be bad, and the consequence of too much of drugs is something we are all familiar with. Not all of us have tried these drugs, but cinema has shown us the most graphic and ...

In this week’s View, Dr. Eagle looks at the consequences of discontinuing long-term drug treatment in patients with heart failure and reduced ejection fraction (HFrEF). He then explores the effect of ...

Alpha-blockers These may be used as an additional treatment option or in combination with other drugs. headaches, nausea, dizziness, tremors, and more Alpha-2 receptor agonists These are primarily ...

MSN Laboratories Pvt. Ltd. urged the Federal Circuit to reconsider a three-judge panel’s January ruling that revived a patent for Novartis AG’s blockbuster heart-disease drug Entresto. The Jan. 10 ...

Objectives To describe the prescribing trends of antihypertensive drugs in primary care patients and assess the trajectory of antihypertensive drug prescriptions, from first-line to third-line, in ...

control; p<0.05 vs. control The Valsartan Heart Failure Trial (Val-HeFT), which used valsartan added to an existing heart failure medication including angiotensin-converting enzyme (ACE ...

Drug addiction is a condition in which there is uncontrolled use of a substance with a harmful outcome. Drugs overstimulate the brain’s reward circuit, producing pleasure or euphoria. With repeated ...

Correspondence to Dr Anastasia D Egorova, Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands; a.egorova{at}lumc.nl Objective Patients with a systemic right ...