During endosome maturation Rab5 is replaced by Rab7 on endosomes that are able to fuse with lysosomes to form endolysosomes. However, whether ESCRT-driven ILV formation and Rab5-to-Rab7 conversion are ...

One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids—key components of LNPs that change their charge to help them escape the endosome.

One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids -- key components of LNPs that change their charge to help them escape the endosome.