Instead of the enzyme mechanism described in biochemistry text-books, hen lysozyme hydrolysis was postulated to occur by a ring-opening mechanism based on substrate interactions defined by the active ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

Meet O-GlcNAc transferase (OGT), an enzyme at the heart of many essential cellular functions ... DNA modifications and TE ...

The transformation of healthy cells into invasive colorectal tumors is an extraordinarily complex process involving numerous ...

A study identifies senolytic compounds that can inhibit specific brain enzymes associated with Alzheimer’s disease (AD) while ...

1). Therefore, the quaternary complex represents a closed form of the m-NAD-ME enzyme, whereas the binary complex with NAD + is an open form of the enzyme. Furthermore, in the binary complex ...

(b. 1964) B.S., 1986, University of Massachusetts, Amherst; Ph.D., 1991, Brown University; National Institutes of Health Postdoctoral Fellow, 1991 – 1994 ...

Scientists have captured the first detailed 'molecular movie' showing DNA being unzipped at the atomic level -- revealing how cells begin the crucial process of copying their genetic material.

Researchers have identified the human enzyme APEH as a crucial activator of antimalarial prodrugs, paving the way for more ...