The authors used gain and loss of function techniques to provide convincing evidence showing that RUNX2 isoform silencing led to cell death via several mechanisms including apoptosis and ferroptosis ...

Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407219, Taiwan R.O.C. Department of Physical Therapy, Hung Kuang ...

In contrast, extrinsic aging is driven by environmental factors ... breakdown processes to eliminate damaged organelles and proteins. Additionally, apoptosis-related pathways were evident, indicating ...

signaling pathway plays a pivotal role in enamel formation. This review firstly elucidates the critical functions of TGF-β1 in regulating ameloblast behavior and enamel development, encompassing ...

H-89 AKT inhibitor, cAMP dependent protein kinase inhibitor, PKA inhibitor, voltage-gated potassium channel blocker Anticancer effects, stimulates apoptosis by inhibiting the PI3K/Akt pathway. (31) ...

or the cell surface receptors (the 'extrinsic' pathway). Mitochondria-mediated apoptosis occurs in response to a wide range of death stimuli, including activation of tumor suppressor proteins ...