A phase 3 trial shows that once-weekly semaglutide significantly improves liver histology in patients with metabolic ...

Clinics and hospitals are getting a substantial uptick in consultations, with many receiving hundreds of calls within days of the drug’s availability US pharmaceutical giant Eli Lilly’s introduction ...

TET2 works with HNF4α to activate the FBP1 gene upon glucagon stimulation, while metformin disrupts TET2-HNF4α interaction, lowering FBP1 levels and improving glucose homeostasis. The results are ...

Studies have shown that AS-IV downregulates the expression of intestinal fibroblast growth factor 15, activates the liver farnesoid X receptor (FXR) signaling pathway, upregulates glucagon-like ...

Background Injured or reactive biliary epithelial cells participate in most chronic liver injuries in a process referred to as ductular reaction, which involves multicellular interactions with marked ...

Drucker and three co-winners made discoveries about glucagon-like peptide-1 in their labs. The other recipient of the award, Lotte Bjerre Knudsen, who works for Novo Nordisk, led the way in ...

In MASLD and MASH, TGF-β signaling contributes to hepatocyte lipid accumulation, cell death and fibrosis progression through both Smad and non-Smad pathways. In HCC, TGF-β and other TGF-β-SF cytokines ...