NEW YORK CITY, NEW YORK / ACCESS Newswire / April 22, 2025 / Neurovation Labs, Inc., a precision neuroscience biotechnology company targeting physiological biomarkers of Post-traumatic Stress Disorder ...

NEW YORK CITY, NEW YORK / ACCESS Newswire / April 22, 2025 /Neurovation Labs, Inc., a precision neuroscience biotechnology ...

The study provides intriguing evidence linking autophagy to the removal of AMPA receptors from the cell membrane of LHb neurons. These receptors respond to the neurotransmitter molecule glutamate ...

Illustration of an AMPA receptor and glutamate. Credit: Edward Twomey, Johns Hopkins Medicine Scientists used advanced cryo-EM imaging to reveal how glutamate activates brain receptors, paving the way ...

These compounds target the ifenprodil binding site of the NMDA receptor and exhibit enhanced metabolic stability compared to traditional phenolic-based molecules. GluN2B-containing NMDARs are members ...

receptor-mediated excitatory synaptic activity and social deficits in MDGA2-deficient mice,” they stated. Based on these results, combined with those of previous research, the authors suggest ...

Summary: Researchers used advanced cryo-electron microscopy to capture atomic-level images of how glutamate, a key neurotransmitter, opens channels in brain cells. These channels, known as AMPA ...

Its landing place on neurons is a channel called an AMPA receptor, which interacts with glutamate, and then acts like a pore that takes in charged particles. The ebb and flow of charged particles ...

Co-written with Jai Liester. Silent synapses represent one of neuroscience's most fascinating discoveries—connections between neurons that lie dormant until activated by specific triggers.

This highlight describes a series of novel 6-aryl isoindolin-1-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor 2 (mGluR 2). The chemical synthesis, ...

Glutamate receptors are required for the induction ... during LTP and LTD. The discovery of proteins that directly bind to AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid) receptor ...