One key pathway is the soluble guanylyl cyclase–cyclic GMP–protein kinase G system. If it is produced in excess, or if a cell is under conditions of oxidative stress, NO becomes noxious and ma ...

The human body relies on three kinds of opioid receptors to regulate pain, much like traffic control systems on a busy highway. Understanding these pathways is key to developing safer pain treatments.

Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University, Chongqing 400712, China National Citrus Engineering ...

Abstract Guanylate cyclase-A, the receptor for atrial natriuretic factor, contains a protein kinase–like domain and a catalytic domain in the intracellular region. To investigate the active site (the ...

NO SIGNALING:© 2003 Annual ReviewsAll images redrawn from D. Boehning, S.H. Snyder, Ann Rev Neurosci, 26:105–31, 2003.Neuronal nitric oxide synthase (nNOS) is localized to NMDA receptors by the ...

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 , United States Department of Pharmacology, University of Colorado Anschutz ...

Microbiota regulate the tryptophan metabolism involved in serotonin production, serotonin acts as a key neurotransmitter in the CNS and ENS, and serotonin receptors play a pivotal role in the ...

We applied a novel dimer avoidance multiplexed polymerase chain reaction next-generation sequencing assay to analyze T (TCR) and B cell receptor (BCR) repertoires. Surprisingly, TCR repertoires were ...