In patients with hypercholesterolemia, ezetimibe added to ongoing HMG-CoA reductase inhibitor therapy significantly lowered total cholesterol, LDL-C, apolipoprotein B, and triglycerides and ...

Changes in lifestyle such as appropriate exercise and diet modification and the prescription of cholesterol-reducing drugs such as statins (inhibitors of the HMG-CoA reductase) will reduce ...

The decrease is likely due to inhibition of HMG CoA R, thereby reducing sterol (including cholesterol) synthesis, as well as presumably 7-DHC and 8-DHC synthesis. Moreover, simvastatin added to ...

Clinical trials employing small-molecule MDM2/p53 interaction inhibitors have demonstrated limited activity, underscoring an unmet need for a better approach to target MDM2. KT-253 is a highly potent ...

The following are statins that are recommended to be taken in the evening or with your dinner: Statins work by stopping the activity of an enzyme called HMG-CoA reductase, a protein that the body ...

Small Molecule Therapeutic Discovery, Amgen Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States ...

Abstract and Introduction Pathophysiology and Implications of Atherosclerosis Emerging Role of Statins Discussion References Current studies have questioned the relationship between CRP and LDL ...

Despite being considered “undruggable”, recent advances in the use of allele-specific covalent inhibitors against the most common mutant form of RAS in non-small-cell lung cancer have led to the ...

DNA damage response inhibitors are widely used anti-cancer agents that have potent activity against tumor cells with deficiencies in various DNA damage response proteins such as BRCA1/2. Inhibition of ...

Diagrammatic representation of RAS, showing site of intervention with ARBs and ACE inhibitors. Abbreviations are as defined in text. Figure 2. Summary of role of cholesterol and hypercholesterolemia ...