The combination product is not recommended for patients with hepatic impairment because losartan is usually initiated in this group of patients at a dosage of 25 mg once daily. The combination ...
losartan (100 mg/day); and losartan (100 mg/day) plus hydrochlorothiazide (25 mg/day). Proteinuria was reduced by 22% from baseline with the low-sodium diet alone and by 30% with losartan alone.
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