The products of six MCM genes, MCM2 to MCM7 (MCM2-7), form a six-subunit ring complex, serving as the catalytic core of the unzipping machine, the DNA replicative helicase. In cells, to initiate ...
Recruitment of these SCF components to chromatin and efficient Xic1 ubiquitination depends on the presence of the Mcm2–7 origin proteins (Fig. 1, right). Since the 'pre-replicative complex' of ...
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