Integral membrane proteins such as receptors and ion channels span the membrane. Peripheral membrane proteins, for example some signalling proteins, are tethered by an anchor, via a fatty acid ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Oregon Health & Science University, in collaboration with Oregon State University, has discovered the structural organization ...

The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a ...

A research team from the Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences, along with collaborators, has introduced a novel membrane design that mimics ...

Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K. Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 ...

Mpf1 is an unstable protein that is associated with the cytosolic face of the mitochondrial outer membrane. This contribution addresses ... carbon source to oleate suggests that such a short life span ...

Molecular dynamics (MD) simulations of membrane proteins cover a wide range of applications and specialized techniques. These techniques accurately combine two challenges into one: properly capturing ...

To reach their final destinations, outer membrane proteins (OMPs) of gram-negative bacteria undertake an eventful journey beginning in the cytosol. Multiple molecular machines, chaperones, proteases, ...

This section will include a comprehensive description of mechanosensitive ion channels, cellular routes of force transmission and signaling membrane microdomains. Finally, we will provide the audience ...

For eight target proteins, including actin-meshwork and membrane-coat proteins ... and allowing a maximum gap of 6 frames (spanning missed localizations in up to four frames), as discussed in the ...

G protein coupled receptors (GPCRs) constitute the largest class of cell surface receptors. GPCR genes account for 5% of the human genome (1, 2). Of these receptors, all are seven membrane spanning ...