G protein-coupled receptors ... that agonist activation of metabotropic glutamate receptors entails population of several intermediary states before G protein coupling. To help in the rational ...

The cascades involve Ca 2+ sensors, protein–protein interactions ... activation of either NMDARs (N-methyl-D-aspartate receptors) or metabotropic glutamate receptors (mGluRs).

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 , United States Department of Pharmacology, University of Colorado Anschutz ...

G protein-coupled receptors (GPCRs) are the target of hundreds of approved drugs. Although these drugs were designed to target individual receptors, it is becoming increasingly apparent that GPCRs ...

Human G-protein coupled receptors (GPCRs) convey a wide variety of extracellular signals inside the cell and they are one of the main targets for pharmaceutical intervention. Rational drug design ...