Protein translocation is an essential, nano-scale dynamic process that facilitates the movement of proteins across cellular ...

Myeloid deficiency of the mitochondrial transacetylase tafazzin upregulates mtROS, disrupting UPR and calcium homeostasis, ...

A research collaboration has found that besides regulating the fusion of mitochondria, Mitofusin 2 also ensures protein quality control. This discovery could open up new routes to treating ...

Cancer cells cripple immune cells by donating their damaged mitochondria, hindering the immune response and fostering tumour ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

The study shows that mitochondria do more than provide energy; they play an active role in modulating the immune response.

A new study published in Biochemistry sheds light on how bacteria regulate their genes, challenging long-held assumptions ...

However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

Mitochondria, often seen as cellular powerhouses, play a surprising role in immune regulation. Researchers found that ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

1% of mitochondrial proteins are encoded by the mitochondrial genome and synthesized in the mitochondrial matrix. The translocase of the outer membrane (TOM) complex is the main entry gate used by ...

Mitochondrial fusion relies on membrane proteins Mfn1/2 and OPA1 residing in the OMM and the IMM, respectively. Mfn1 and Mfn2 form homo-oligomeric (Mfn1-Mfn1 or Mfn2-Mfn2) and hetero-oligomeric ...