Autophagic flux was examined by the buildup of p62 or ubiquitinated organelle protein. Endolysosomal structures were examined by electron microscopy. Cell-specific autophagy was evaluated by ...

This Patent Highlight integrates bifunctional degraders, leveraging autophagy via p62, and substituted oxazolone compounds targeting IKZF1–4 transcription factors. These compounds demonstrate ...

p < 0.05 was considered as statistically significant. Beclin1, LC3 and P62 are autophagy-related proteins. Therefore, the expression levels of Beclin-1, LC-3B, and P62 were detected by the Western ...

The Role of p62: A Key Player in Cell Cleanup A protein called p62 is essential for autophagy. It helps clean out harmful protein clumps like alpha-synuclein. However, the Scripps Research team fo ...

Parkinson’s disease is a brain disorder that affects movement, making everyday tasks difficult for nearly one million people in the U.S. It happens when brain cells that produce dopamine—an important ...

P < 0.05, ** P < 0.01. Fig. 2 Colocalization of mHTT with p62, Ub and CTSD. (A) Triple labeling detects colocalization of mHTT with both autophagy adaptor proteins p62 and Ub. Brain sections from 6-mo ...

The DF-O and MPs samples suppressed autophagy by decreasing expression levels of microtubule ... while increasing the level of p62. Meanwhile, DF-O and MPs samples induced apoptosis through increasing ...

cGAS can also act as a selective autophagy receptor for micronuclei causing their ultimate degradation and thereby prohibiting them from releasing DNA into the cytosol. Finally, K48-linked ...

MANILA, Philippines — Profit of Ayala-led Bank of the Philippine Islands (BPI) jumped by 20 percent to hit an all-time high of P62 billion in 2024 from the previous year’s P51.7 billion ...

In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteome ...