Parkinson’s disease is a brain disorder that affects movement, making everyday tasks difficult for nearly one million people ...

Autophagic flux was examined by the buildup of p62 or ubiquitinated organelle protein. Endolysosomal structures were examined by electron microscopy. Cell-specific autophagy was evaluated by ...

This Patent Highlight integrates bifunctional degraders, leveraging autophagy via p62, and substituted oxazolone compounds targeting IKZF1–4 transcription factors. These compounds demonstrate ...

Double fluorescence immunolabeling and immuno-electron microscopy (IEM) revealed colocalization of HTT/mHTT with the autophagy-related adaptor proteins, p62/SQSTM1 and ubiquitin, and cathepsin D (CTSD ...

The DF-O and MPs samples suppressed autophagy by decreasing expression levels of microtubule ... while increasing the level of p62. Meanwhile, DF-O and MPs samples induced apoptosis through increasing ...

As the reviewer pointed out, changes in the LC3-II/LC3-I ratio do not necessarily indicate autophagy defects. However, since p62 accumulation (Figure 2B, 2E, 3E, 6C, 7C in the original manuscript), ...

Plants mobilize the endomembrane system for restoring homeostasis when stimulated by stresses. Though the function of ufmylation in ER stress and autophagy has been described in mammals, their ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...