Parkinson’s disease is a brain disorder that affects movement, making everyday tasks difficult for nearly one million people ...

MANILA, Philippines — Profit of Ayala-led Bank of the Philippine Islands (BPI) jumped by 20 percent to hit an all-time high of P62 billion in 2024 from the previous year’s P51.7 billion ...

Autophagic flux was examined by the buildup of p62 or ubiquitinated organelle protein. Endolysosomal structures were examined by electron microscopy. Cell-specific autophagy was evaluated by ...

The decreased transcription level of RILP after diabetic mice suffer from I/RI may lead to abnormal autophagy flux. 3.2.4 RILP protein expression was significantly decreased after I/RI in diabetic ...

This Patent Highlight integrates bifunctional degraders, leveraging autophagy via p62, and substituted oxazolone compounds targeting IKZF1–4 transcription factors. These compounds demonstrate ...

P < 0.05, ** P < 0.01. Fig. 2 Colocalization of mHTT with p62, Ub and CTSD. (A) Triple labeling detects colocalization of mHTT with both autophagy adaptor proteins p62 and Ub. Brain sections from 6-mo ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. mTOR plays a pivotal role in cancer growth ...

The DF-O and MPs samples suppressed autophagy by decreasing expression levels of microtubule ... while increasing the level of p62. Meanwhile, DF-O and MPs samples induced apoptosis through increasing ...

The Role of p62: A Key Player in Cell Cleanup A protein called p62 is essential for autophagy. It helps clean out harmful protein clumps like alpha-synuclein. However, the Scripps Research team fo ...

In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteome ...