RNA polymerase is an enzyme that is responsible ... there are striking similarities among transcriptional mechanisms. For example, all species require a mechanism by which transcription can ...

it is first necessary to examine the mechanisms of RNA transcription in more detail. In bacteria, all transcription is performed by a single type of RNA polymerase. This polymerase contains four ...

The findings demonstrate that, under certain circumstances, the RNA polymerase (RNAP ... so cells have many redundant mechanisms to prevent them from forming," says Seth Darst, head of the ...

mRNA transcription by RNA polymerase II (Pol II) is rapidly regulated in response ... We take advantage of high-throughput sequencing approaches to investigate the mechanisms that control genome-wide ...

"When SPT5 is lost, this ARMC5 mechanism will recognize RNA polymerase II and then eliminate this defective transcription complex." The findings may also inform the understanding of the ...

RNA cleavage can occur either: (i) by a transesterification mechanism that yields 2’,3’-cyclic-PO 4 and 5’-OH ends; or (ii) via a hydrolytic mechanism that leaves 3’-OH and 5’-PO 4 ends. RNA repair ...

Trends Biochem Sci 2022, 47: 314 - 327. Palacio, M; Taatjes DJ. Merging established mechanisms with new insights: Condensates, hubs, and the regulation of RNA polymerase II transcription. J Mol Biol ...

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches ...

There are a variety of different types of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main ...