Promoter sequences are DNA sequences that define where transcription of a gene by RNA polymerase begins. Promoter sequences are typically located directly upstream or at the 5' end of the ...

This polymerase contains four catalytic ... sequences in the DNA), these elements constitute the core promoter. However, changes in RNA pol II affinity and, therefore, gene expression can be ...

Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results from a combination of higher Pol II turnover and lower transcription ...

These proteins impart on RNA polymerase the ability both to recognize promoter DNA, and to orchestrate the strand separation that accompanies formation of a transcription-competent RNA ...

The process of transcription elongation by RNA polymerase II (Pol II), in which Pol II travels along DNA and synthesizes RNA from DNA, is essential for proper gene expression in all eukaryotic cells.

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II ... dependent kinases which trigger Pol II release from ...