specifically Integrator complex subunit 12 (INTS12). Integrator functions as a genome-wide attenuator of transcription that acts on elongation through its RNA cleavage and phosphatase modules.

Introduction: RNA polymerase III (Pol III) is a critical enzymatic complex ... and confirmed that Pol III also plays a critical role in myelinogenesis. Decreasing Pol III subunit expression in ...

Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and proliferation and a consistent feature of cancer cells. We have ...

We have performed ChIP-seq experiments on tightly staged Drosophila embryos and show that massive recruitment of RNA polymerase II (Pol II ... However, both TATA-box binding protein (TBP), the key ...