To compound matters, tamoxifen is a two-edged sword. Although it opposes estrogen activity in the breast, it is an estrogen mimetic in the uterus, an important consideration in its prophylactic ...

Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss hormonal therapy updates and different ways to target and ...

Aromatase inhibitors work differently than Tamoxifen; they actually lower the amount of estrogen the body produces. There's also evidence that they may be more effective drugs. The landmark ATAC ...

This is the second installment of a three-part series on breast cancer.] The most common breast cancer symptom is a lump. Other symptoms include swelling, skin irritation, nipple pain or ...

and estrogen-receptor-positive tumor), local relapse was uncommon in both the tamoxifen-alone and tamoxifen-plus-radiation groups (1.2% vs. 0%). A U.S. study involved 636 older women (age ...

The Fuqua laboratory has determined that the K303R mutation alters many aspects of hormone action, including binding to co-regulatory proteins, enhanced stability, estrogen hypersensitivity, response ...