Antibodies have become the Swiss Army tool for molecular biology and nanotechnology. Their outstanding ability to specifically recognise molecular antigens allows their use in many different ...

Ema2 interacts with the SUMO E2 conjugating enzyme Ubc9 and enhances SUMOylation of the transcription regulator Spt6. We further show that Ema2 promotes the association of Spt6 and RNA polymerase II ...

Approximately one-quarter of the patients were tested for paraneoplastic antibodies, including anti-Hu, anti-Yo, anti-Ri, and anti-amphiphysin. The initial dilution titers of serum and CSF were 1:10 ...

The single E2 (UBC9) facilitates the hand-off and covalent conjugation of SUMO on a given protein substrate. Although E3s are believed to guide substrate selectivity in cells, only E1 and E2 are ...