Characterisation of the models will confirm genetic, molecular and cellular defects relating to cilia motility, prior to high throughput testing of novel therapies. Through the national LifeArc ...

Researchers have discovered that a single molecule, Wnt3, coordinates a two-step process of cell polarity orientation that enables jellyfish embryos to develop around a central axis, shedding light on ...

Cilia are only assembled during the G 0 (the period in which ... The Wingless-related integration site (Wnt) is an evolutionary conserved signaling pathway that regulates key features during ...

Wnt signaling is causative for EMT, whereas the mechanism in CRSwNP is not fully understood. Objective We sought to evaluate the role of Wnt signaling in EMT of CRSwNP using a murine nasal polyp (NP) ...

Primary cilia have emerged as key organelles in Hh signal transduction in mammalian systems and play a role in BCC. The requirement for canonical Wnt/β-catenin signaling in Hh-driven BCC ...

Moreover, the expression of VEGF was restored to wild-type levels in double mutants (p = 0.9545) (Fig 5a and b). Cilia loss in the middle ear cavities of Dp5Tyb mice and littermate controls. Scanning ...

Simplified view of canonical Notch, Hedgehog, and Wnt signaling pathway in cancer ... In the absence of ligands, Ptch1 inhibits SMO accumulation in primary cilia, thereby resulting in the block of the ...