US stock futures sank as Wall Street reacted to President Trump's massive tariffs on key US trading partners taking full effect on Wednesday at 12:01 a.m. China has been hit with whopping 104% duties,

Trump said he’s not considering pausing his recently imposed tariffs but is willing to negotiate the duties with other nations.

Asian stocks were mostly lower and US stock futures tumbled Wednesday after President Donald Trump’s enormous “reciprocal” tariffs went into effect, upending global trade.

Since he unveiled a sweeping set of tariffs on April 2nd, some 70 countries have contacted the White House, hoping to win relief. After Mr Trump’s tariffs came into effect on April 9th, their efforts will now become a good deal more frantic.

Business owners say the rapid change in US trade policy, including major tariffs on China, has left operations in flux.

Investors braced for another rocky day of trading. South Korea and Japan are sending delegations to Washington to negotiate, while China says it will fight the latest levies.

President Donald Trump's "reciprocal" tariffs on dozens of countries were set to take effect on Wednesday, including massive 104% duties on Chinese goods, deepening his global trade war even as he prepared for negotiations with some nations.

Delegations from Japan and South Korea are en route. Italy’s prime minister will be in Washington next week. And Israel’s “proactive approach” to seeking out new US trade agreements could serve as a model for everyone,

Trump has described the tariffs as "reciprocal," saying the steep toll will correct a grievance he's held for "35 years:" that the U.S. is being "ripped off" by trade imbalances. The president has claimed the tariffs will prompt countries to try to negotiate a deal with the U.