DNA polymerase II (also known as DNA Pol II or Pol II) is a prokaryotic DNA-dependent DNA polymerase encoded by the PolB gene. [1] DNA Polymerase II is an 89.9-kDa protein and is a member of the B family of DNA polymerases.

Aug 8, 2023 · Prokaryotic organisms like bacteria include an enzyme called DNA polymerase II (Pol II) that is used in the replication and repair of DNA. It belongs to the family of DNA polymerase B, which also includes a number of other DNA …

Nov 7, 2023 · DNA polymerases are enzymes that synthesize new copies of DNA, the double-stranded genetic material of our cell. Just before a cell divides during cell division, DNA polymerases copy the double-stranded parent strand into two identical DNA molecules by a process known as DNA replication.

DNA polymerase II was discovered by Thomas Kornberg (the son of Arthur Kornberg) and Malcolm E. Gefter in 1970 while further elucidating the role of Pol I in E. coli DNA replication. [8] .

Oct 10, 2024 · DNA Polymerase II is an enzyme involved in DNA replication, synthesizing new DNA strands and correcting errors to maintain genomic integrity. Understanding its structure and function provides insights into cellular processes and …

Aug 3, 2023 · In a eukaryotic cell, there are five main DNA polymerase: DNA Polymerase α, ε, δ, γ, and β. Since in eukaryotic cells, in addition to nuclear DNA, there is also the presence of mitochondrial DNA, which accounts for the fact that the replication of DNA happens in two different cellular compartments.

DNA polymerase II (pol II) is a single polypeptide of 783 amino acids with a predicted mass of 89.9 kDa, and is encoded by the polB (a.k.a. dinA) gene. DNA pol II is the founding member of the B family of DNA polymerase structures, and contains the five motifs characteristic of this family, including both DNA polymerase and exonuclease domains.

Jun 3, 2023 · DNA polymerases are a group of enzymes that are used to make copies of DNA templates, essentially used in DNA replication mechanisms. These enzymes make new copies of DNA from existing templates and also function by repairing the synthesized DNA to …

Jun 1, 2024 · DNA polymerase II (DNA Pol II) is a prokaryotic DNA-dependent DNA polymerase that primarily functions as a backup enzyme in DNA replication and repair processes. It belongs to the B family of DNA polymerases and possesses DNA synthesis and proofreading activities.

Mar 1, 2021 · DNA polymerase II is a member of the B family of DNA polymerases. It is involved both in replicative and reparative processes, particularly in a 5’ 3′ DNA-dependent DNA polymerase activity and in 3’ 5′ exonuclease proofreading activity.