These surface molecules are referred to as “death receptors,” and their mode of caspase activation is called the death receptor pathway of apoptosis. The death receptors and the …

Jan 1, 2005 · Death receptors are important in inducing apoptosis and together with their ligands have become a source of attention as potential therapeutic agents. This review provides an …

Death receptor-mediated apoptosis can be inhibited by a protein called c-FLIP which will bind to FADD and caspase-8, rendering them ineffective (Kataoka et al., 1998; Scaffidi, 1999). …

Several signaling pathways contribute to apoptosis, with the intrinsic (mitochondrial) and extrinsic (death receptor) pathways being the main ones. Initiator caspases (caspase-8 and -9) and …

Jan 16, 2025 · Death receptor signaling is one pathway through which apoptosis can be initiated. Researchers aim to develop targeted therapies that could selectively trigger cell death in …

Jun 15, 1998 · Death receptors have been recently identified as a subgroup of the TNF-receptor superfamily with a predominant function in induction of apoptosis. The receptors are …

Dec 18, 2023 · The activation of death receptors, including TNFR1, Fas, DR4 and DR5, by their cognate ligands in cells under apoptosis-deficient conditions can promote necroptosis.

Aug 28, 1998 · Death receptors—cell surface receptors that transmit apoptosis signals initiated by specific “death ligands”—play a central role in instructive apoptosis. These receptors can …

Mar 1, 2024 · TNF (tumor necrosis factor)-related apoptosis-inducing ligand (TRAIL) is one route of particular interest since it causes apoptotic cell death in cancerous cells upon binding to its …

Explore apoptosis through death receptors signaling pathway and find antibodies to detect some of its target proteins, including Fas Ligand, CD95 and TNF alpha.