The cheapest way to get from South Carolina to Des Moines costs only $267, and the quickest way takes just 4 hours. Find the travel option that best suits you.

The cheapest way to get from South Carolina to Iowa costs only $233, and the quickest way takes just 5 hours. Find the travel option that best suits you.

Find airfare and ticket deals for cheap flights from South Carolina to Des Moines. Search flight deals from various travel partners with one click at $56.

There are 9 ways to get from Des Moines to South Carolina by plane, bus, train, night bus, or car. Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Find flights to Des Moines from $131. Fly from South Carolina on Frontier, American Airlines, Allegiant Air and more. Search for Des Moines flights on KAYAK now to find the best deal.

Fly one-way from Greenville-Spartanburg to Des Moines starting at $224. Bundle your Southwest Airlines® flight with a hotel or rental car booking and find even more savings.

Discover carefully curated flight deals from South Carolina to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 8, 2025.

Cheap Flights from Columbia (CAE) to Des Moines (DSM) start at $211 for one-way and $248 for round trip. Earn your airline miles on top of our rewards!

Find flights to Iowa from $56. Fly from South Carolina on Frontier, American Airlines, Delta and more. Search for Iowa flights on KAYAK now to find the best deal.

How long is the drive from Columbia, SC to Des Moines, IA? The total driving time is 16 hours, 4 minutes. Your trip begins in Columbia, South Carolina. It ends in Des Moines, Iowa. If you're planning a road trip, you might be interested in seeing the total driving distance from Columbia, SC to Des Moines, IA.