With a novel mechanism of action and a single, needle-free application into the surgical site, ZYNRELEF provides patients with up to 72 hours of postoperative pain relief and has been proven to reduce, possibly even eliminate, the need for opioids after surgery.

ZYNRELEF® (bupivacaine and meloxicam) extended-release solution is approved in adults for instillation to produce postsurgical analgesia for up to 72 hours after soft tissue and orthopedic surgical procedures including foot and ankle, and other procedures in which direct exposure to articular cartilage is avoided.

ZYNRELEF is the first and only extended-release dual-acting local anesthetic. 1-4 Its unique formulation combines the local anesthetic bupivacaine with a low dose of the NSAID meloxicam and was designed to overcome the challenges of inflammation at the surgical site.

ZYNRELEF patients experienced superior pain relief through 72 hours—when pain is most severe—compared to patients receiving the current standard of care, bupivacaine HCl solution, making ZYNRELEF the first and only product to demonstrate superiority over bupivacaine HCl solution in Phase 3 studies.

Apr 2, 2024 · Zynrelef is used in adults to relieve pain for up to 72 hours after certain surgical procedures. Zynrelef may also be used for purposes not listed in this medication guide.

Dec 3, 2024 · ZYNRELEF is a viscous solution supplied as a kit consisting of a single-dose glass vial, and the following sterile components: Luer lock syringe (s), a vented vial spike or vial access needle, Luer lock cone-shaped applicator (s), and syringe tip cap (s).

ZYNRELEF is indicated in adults for soft tissue or periarticular instillation to produce postsurgical analgesia for up to 72 hours after foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Aug 24, 2022 · Zynrelef (bupivacaine / meloxicam) is a medication used after surgery to provide pain relief. It's a combination of a local anesthetic (numbing medication), bupivacaine, and a non-steroidal anti-inflammatory drug (NSAID), meloxicam. Bupivacaine works to numb the area by blocking the nerves from sending pain signals to your brain, and meloxicam ...

ZYNRELEF is indicated in adults for instillation to produce postsurgical analgesia for up to 72 hours after soft tissue and orthopedic procedures including foot and ankle, and other procedures in which direct exposure to articular cartilage is avoided.

Two main studies in 830 patients have shown that Zynrelef is effective at reducing pain from small to medium-sized wounds following surgery. The main measure of effectiveness was a total pain score for a 72-hour period, with lower scores indicating better pain control.