Apr 14, 2023 · Irradiated blood and blood components are cellular blood products that have been subjected to radiation with gamma rays or X-rays. Irradiated blood and components are used for transfusion in patients at risk for transfusion-associated graft-versus-host disease (TA- GVHD).

Why does blood need to be irradiated? Who needs irradiated products? What happens if they get non-irradiated products? Whose responsibility is it anyway?

Procedures for Gamma Irradiation of Blood Products. This memorandum transmits recommendations regarding license amendments and procedures pertinent to irradiated blood and blood...

Gamma irradiation, although effective in preventing TA-GVHD, has some drawbacks. It involves the use of a radioactive source, which is subject to stringent health and safety regulations. The machines are also very expensive to buy and decommission when no longer required.

Transfusion-associated graft-vs-host disease (TA-GVHD) is a serious risk for certain severely immunosuppressed or immunodeficient patients. Cellular components for at-risk patients should be irradiated with a minimum of 2,500 cGy (rads) prior to transfusion.

Why is Blood Irradiated? Cellular blood components are irradiated prior to transfusion to prevent the proliferation of viable T lymphocytes which are the immediate cause of Transfusion Associated-Graft Versus Host Disease (TA-GVHD).

All recipients (adult and paediatric) of allogeneic HSCT should receive irradiated blood components from the time of initiation of conditioning chemo/radiotherapy. The recommendation applies for all conditions where HSCT is indicated regardless of the underlying diagnosis .

May 11, 2020 · To provide healthcare professionals with clear guidance on situations when the use of irradiated blood components is indicated. The term ‘blood component’ means the therapeutic constituents of human blood (red cells, white cells, platelets and plasma) that can be prepared by various methods (JPAC https://www.transfusionguidelines.org/red ...

Gamma or X-irradiation of blood components, by validated systems, is the recommended procedure to prevent TA-GvHD (1B). 50 Gy (1B). For at-risk patients, all red cell, platelet and granulocyte concentrates should be irradiated except cryopreserved red cells after deglycerolization.

Gamma or X-irradiation of blood components is indicated to reduce the risk of transfusion-associated GVHD. Risk depends on: Number of viable lymphocytes. Susceptibility of the immune system to engraftment. Degree of HLA-matching (higher risk when donor and recipient share a HLA haplotype). Clinical features: Deranged LFT (hepatitis) Widespread ...