- Copilot AnswerDisease phenotype
ALGS is an autosomal dominant multi-system disorder affecting several body systems including the liver, heart, skeleton, eye, facial structure, kidneys and vascular system. The most clinically significant concerns st… See more
- Jagged1 (JAG1) is one of five cell surface proteins (ligands) that interact with four receptors in the mammalian Notch signaling pathway. The Notch signaling pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems.Learn more:Jagged1 (JAG1) is one of five cell surface proteins (ligands) that interact with four receptors in the mammalian Notch signaling pathway. The Notch signaling pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems.en.wikipedia.org/wiki/JAG1Jagged1 (JAG1) is one of 5 cell surface ligands that functions primarily in the highly conserved Notch signaling pathway. Notch signaling plays a critical role in cellular fate determination and is active throughout development and across many organ systems.pmc.ncbi.nlm.nih.gov/articles/PMC4673022/Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell interactions. JAG1 overexpression has been reported in many different types of cancer and correlates with a poor clinical prognosis.www.sciencedirect.com/science/article/pii/S075333…Skin-resident regulatory T cells (Tregs) play an irreplaceable role in orchestrating cutaneous immune homeostasis and repair, including the promotion of hair regeneration via the Notch signaling ligand Jagged-1 (Jag1).www.nature.com/articles/s41598-024-71512-1
Jagged1 (JAG1): Structure, Expression, and Disease Associations
Jagged1 (JAG1) is one of 5 cell surface ligands that functions primarily in the highly conserved Notch signaling pathway. Notch signaling plays a critical role in cellular fate determination and …
Soluble OX40L and JAG1 Induce Selective Proliferation of ... - Nature
Jan 3, 2017 · In the present study, we demonstrate that soluble OX40 L and JAG1 along with IL-2 were sufficient to cause Treg proliferation in the absence of TCR stimulation. Unlike TCR …
- Author: Prabhakaran Kumar, Khaled Alharshawi, Palash Bhattacharya, Alejandra Marinelarena, Christine Haddad,...
- Publish Year: 2017
The oncogenic role of Jagged1/Notch signaling in cancer
Sep 1, 2020 · Notch signaling driven by the JAG1-expressing cancer or non-cancer cells together with other oncogenic pathways positively regulates tumorigenic cell properties, mainly …
- Author: Meng-xi Xiu, Yuan-meng Liu, Bo-hai Kuang
- Publish Year: 2020
The Notch ligand Jagged1 as a target for anti-tumor …
Sep 24, 2014 · Jagged1 (JAG1) is one of the five canonical ligands for Notch receptors expressed by mammalian cells. Along with Jagged2 (JAG2), it belongs to the Serrate/Jagged family, as opposed to the Delta/Delta-like family of …
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Tumor-derived Jagged1 promotes cancer progression …
Mar 8, 2022 · Our results suggest that Jagged1 promotes tumor progression by modulating the adaptive immune microenvironment because Jagged1 activates Notch signaling in tumor cells and recruited macrophages to suppress …
OX40L-JAG1 induced expansion of lineage-stable regulatory T …
Dec 12, 2019 · The use of Src kinase inhibitor permitted us to demonstrate selective inhibition of TCR-dependent T-cell proliferation with little to no effect on OX40L-JAG1 induced TCR …
JAG1 overexpression contributes to Notch1 signaling …
Sep 19, 2018 · Our results suggest that targeting JAG1 can block Notch1 activation in HTLV-I-transformed cells and represents a new target for immunotherapy in ATL patients. The Notch pathway is one of the most …
Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains …
Dec 9, 2014 · Deregulated Notch signaling has been extensively linked to T-cell acute lymphoblastic leukemia (T-ALL). Here, we show a direct relationship between Notch3 receptor …
JAG1-Mediated Notch Signaling Regulates Secretory …
JAG1 over-expression in BC increased secretory cell differentiation, with no effect on ciliated cell differentiation. Conversely, knockdown of JAG1 decreased expression of secretory cell genes. These data demonstrate JAG1-mediated …
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