In this review, Ng and Shyh-Chang review recent metabolomic studies of stem cell metabolism that have revealed how metabolic pathways can convey changes in the extrinsic environment or their niche to program stem cell fates.

Jan 1, 2024 · Metametabolomics analyzes metabolites using statistical and computational modeling. Moreover, computational biology, stem cell tissue engineering, and cheminformatics analyze the various decisive features of protein–drug and protein–protein interaction networks, including proper analysis of metabolomic, transcriptomic, genomic, and proteomic data.

Feb 18, 2025 · Recent applications of metabolomics, the study of concentrations and fluxes of small molecules in cells, have advanced efforts to characterize and maturate stem cell fates, assess drug toxicity in stem cell tissue models, identify biomarkers, and study the effects of environment on metabolic pathways in stem cells and their progeny.

Here, we discuss four key areas of opportunity in which technology can play a role: biological manipulation, advanced characterization, process automation and personalized medicine. This encompasses key developments in transdifferentiation, gene editing, spatially-resolved -omics and 3D bioprinting.

Apr 16, 2025 · Stem cells offer immense promise for tissue engineering, given their capacity to differentiate into various cell types representative of different tissues and organs 1,2,3,4,5,6,7.However, the ...

Cheminformatics, metabolomics, and stem cell tissue engineering: a transformative insight. Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review. Computational Biology for Stem Cell Research seamlessly bridges the gap between the worlds of biomedical sciences and in silico computational methods.

Here we describe the methods of applying metabolomics, 13 C-labeled glucose and glutamine tracing with mouse embryonic stem cells (ES cells), metabolite analysis using mass spectrometry tools, and the following statistical and computational modeling analysis.

This review clearly demonstrates the current enticing promise of metabolomics in significantly contributing towards a deeper knowledge on SC behavior, and the discovery of new biomarkers of SC function with potential translation to in vivo clinical practice.

Aug 13, 2019 · Here, we provide a comprehensive review of plausible metabolic switches in response to implantation and of the various strategies currently used to leverage MSC metabolism to improve stem cell-based therapeutics.

Jan 1, 2024 · Tissue engineering, relying on a combination of biomaterial scaffolds, cells, and bioactive molecules, has emerged as a promising strategy for the treatment of bone defects.