Dec 10, 2021 · The transfusion of red blood cells (RBCs) is a crucial treatment for sickle cell disease (SCD). While often beneficial, the frequent use of transfusions is associated with numerous complications. Transfusions should be offered with specific guidelines in mind.

Blood transfusion remains an important therapeutic intervention in patients with sickle cell disease (SCD), aiming to both increase the oxygen carrying capacity of blood and to reduce the complications of vaso-occlusion.

Jan 27, 2020 · Most patients with SCD will have received a blood transfusion by the time they reach adulthood, either acutely for the management of SCD-related complications for preoperative preparation, or chronically to prevent neurologic and cardiopulmonary complications.

Jun 23, 2022 · People with sickle cell disease often need blood transfusions. We review the benefits, risks, procedure, and more.

Transfusion of red blood cells (RBCs) remains a first-line therapy for many complications associated with SCD and can be life-saving. Blood transfusion carries risks, many of which are greater in individuals with SCD than in the general population.

The red blood cell products used for transfusion in patients with SCD should all be leukocyte-reduced, sickle hemoglobin negative, matched for at least the red cell antigens Cc, Ee, and K and any antigens for which the patients has developed alloantibodies (past or present).

Transfusions decrease the percentage of red blood cells that are sickled. This can help treat severe anemia or reduce the risk of stroke and other complications of blocked blood flow. There are potentially serious risks of blood transfusions, including allergic reactions and iron overload.

Blood transfusion has been a cornerstone of treatment for SCD, offering a critical intervention for both acute and chronic complications. Transfusion therapy aims to reduce the proportion of sickled erythrocytes in circulation, improving oxygen delivery and reducing the risk of VOC and other complications.

Transfusions can be given for either acute or chronic complications of SCD. Blood transfusion in sickle cell disease (SCD) can be potentially lifesaving but can also be associated with morbidity.

Aug 16, 2024 · A blood transfusion is a medical procedure through which healthy blood cells or blood components are transferred from a healthy donor to someone in need. It may be used to help treat, mitigate, or prevent the symptoms and chronic complications of sickle cell disease (SCD) in both children and adults.