May 22, 2023 · Scleroderma and lupus have similarities, but they are distinct conditions. Both conditions occur due to autoimmunity, which is when the immune system attacks the body’s healthy tissues. Both...

As scleroderma is an immune system disorder, these patients may have other autoimmune diseases, such as systemic lupus erythematosus, or lupus. In fact, lupus affects an estimated 20 percent of all scleroderma patients. Such related conditions are often called overlapping or crossover diseases.

Scleroderma is one of the most common “overlap diseases” for those living with lupus, with about 20% of those with scleroderma also having lupus. Learn about the complexities of scleroderma including its symptoms, possible complications and the most common ways to manage this autoimmune disease.

Lupus Erythematosus and Scleroderma are classified as vascular diseases, along with polyarteritis nodosa, and some other diseases, but Lupus and Scleroderma also have one other thing in common – they can be treated in a similar manner with equally good results!

Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are two phenotypically distincts inflammatory systemic diseases. However, SLE and SSc share pathogenic features such as interferon signature, loss of tolerance against self-nuclear antigens and increased tissue damage such as fibrosis. …

Scleroderma and Systemic Lupus Erythematosus (SLE) are both autoimmune diseases that can affect multiple organs in the body. While they share some similarities in terms of symptoms and treatment, there are also key differences between the two conditions.

The pathogenesis of connective tissue diseases (CTDs), such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), is characterized by derangements of the innate and adaptive immune system, and inflammatory pathways leading to autoimmunity, chronic cytokine production, and chronic inflammation.

Key words: Celiac Disease; Lupus Erythematosus, Systemic; Scleroderma, Systemic. Introduction. Multiple autoimmune syndromes (MAS) are described as the coexistence of more than 2 autoimmune disorders. MAS are due to the underlying immune dysregulation pathways and shared genetic polymorphisms that make the overlap more likely.

May 18, 2019 · Patients with either diffuse cutaneous or limited cutaneous SSc sometimes develop systemic lupus erythematosus (SLE) as well. A new, large cohort study published in the Journal of Rheumatology reveals details on the epidemiology, clinical signs and survival data of SSc-SLE overlap syndrome.1.

The objective of this chapter is to describe the neurological manifestations of three of the most common systemic autoimmune disorders: systemic lupus erythematosus (SLE), scleroderma, and Sjögren's syndrome (SS).