The Notch signaling pathway is a critical component of cardiovascular formation and morphogenesis in both development and disease. It is required for the selection of endothelial …

Mar 24, 2022 · NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes. NOTCH signaling deeply participates in the …

May 27, 2024 · Accumulating evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer types. Dysregulation of this …

Mar 10, 2025 · This Review discusses how different modes of Notch signalling can have different functional outcomes, and how their dysregulation is associated with cancer states.

The Notch signaling pathway is a communication system between cells that regulates various cellular processes, including cell proliferation, differentiation, and cell fate determination. It is …

This review describes the core developmental logic of Notch signaling and how regulatory mechanisms tailor Notch pathway outputs to specific developmental scenarios.

Mar 24, 2022 · In this review, we focus on both classical and the latest findings related to NOTCH signaling to illustrate the history, architecture, regulatory mechanisms, contributions to …

Feb 4, 2025 · The Notch signaling pathway is a crucial communication system influencing cell differentiation, proliferation, and apoptosis. Its significance extends from embryonic …

4 days ago · The Notch signaling pathway is highly conserved and promotes communication between adjacent cells. 7 It can also regulate cellular activities, such as cell proliferation, …

The Notch pathway mediates juxtacrine cellular signaling wherein both the signal sending and receiving cells are affected through ligand-receptor crosstalk by which an array of cell fate …