Clostridioides Difficile Infection (CDI) Pathogen: - Anaerobic, gram-positive, rod-shaped bacterium with spore formation - Spores have tolerance to heat, desiccation and many disinfectants. - Two exotoxins: toxin A (“enterotoxin”) and toxin B (“cytotoxin”) - Careful: the hypervirulent strain: NAP-1,ribotype 027, III has increased expression of toxins A and B. Risk Factors: - Main risk factors: previous antibiotic therapy, hospitalization, age > 65 years - Other risk factors: multimorbidity, fema